B-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-Boronic acid
[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid
CAS: 344591-91-9
Molecular Formula: C5H6BF3N2O2
B-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-Boronic acid - Names and Identifiers
B-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-Boronic acid - Physico-chemical Properties
| Molecular Formula | C5H6BF3N2O2 |
| Molar Mass | 193.92 |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Melting Point | 132-137°C |
| Boling Point | 311.3±52.0 °C(Predicted) |
| Flash Point | 142.042°C |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | powder or crystals |
| pKa | 6.97±0.58(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.463 |
B-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-Boronic acid - Risk and Safety
| WGK Germany | 3 |
B-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-Boronic acid - Introduction
[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid is an organic compound with the chemical formula C6H6BF3N2O2.
Nature:
-Appearance: Colorless crystalline solid
-Molecular weight: 197.83g/mol
-melting point: 139-141 ℃
-Boiling point: 344.8 ℃ (expected value)
-Solubility: Soluble in common solvents such as water, methanol and ethanol
Use:
- [1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid is an organoboron reagent, widely used in organic synthesis.
-it can be used as a catalyst or raw material to participate in carbene reaction, coupling reaction, hydrogenation reaction and other organic synthesis reaction.
Preparation Method:
A common method for preparing [1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid is by reacting sodium borate with 1-methyl-3-trifluoromethylpyrazole. Specific steps are:
1. first dissolve sodium hydroborate in water or ethanol;
2. add 1-methyl -3-trifluoromethylpyrazole;
3. Stir the reaction at an appropriate temperature for a period of time;
4. The product is obtained by filtering the precipitate.
Safety Information:
- [1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid is relatively stable at room temperature, but high temperatures, open flames and strong oxidants should be avoided.
-Use when wearing appropriate protective measures, such as wearing chemical goggles and protective gloves.
-Avoid contact with skin, eyes and inhalation of vapors or dust during operation.
-In case of accidental contact, rinse immediately with plenty of water and seek medical assistance nearby.
Nature:
-Appearance: Colorless crystalline solid
-Molecular weight: 197.83g/mol
-melting point: 139-141 ℃
-Boiling point: 344.8 ℃ (expected value)
-Solubility: Soluble in common solvents such as water, methanol and ethanol
Use:
- [1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid is an organoboron reagent, widely used in organic synthesis.
-it can be used as a catalyst or raw material to participate in carbene reaction, coupling reaction, hydrogenation reaction and other organic synthesis reaction.
Preparation Method:
A common method for preparing [1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid is by reacting sodium borate with 1-methyl-3-trifluoromethylpyrazole. Specific steps are:
1. first dissolve sodium hydroborate in water or ethanol;
2. add 1-methyl -3-trifluoromethylpyrazole;
3. Stir the reaction at an appropriate temperature for a period of time;
4. The product is obtained by filtering the precipitate.
Safety Information:
- [1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]boronic acid is relatively stable at room temperature, but high temperatures, open flames and strong oxidants should be avoided.
-Use when wearing appropriate protective measures, such as wearing chemical goggles and protective gloves.
-Avoid contact with skin, eyes and inhalation of vapors or dust during operation.
-In case of accidental contact, rinse immediately with plenty of water and seek medical assistance nearby.
Last Update：2024-04-10 22:29:15
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CAS: 344591-91-9
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